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고압산소요법 연구논문

관리자
2018-10-21
조회수 953

고압산소요법 연구논문

출처: http://www.medscimonit.com/download/index/idArt/428463



Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy.

고압산소와 악성종양: 방사선요법, 화학요법, 종양 수술과 광선요법에서 잠재적 역할

Med Sci Monit. 2005 Sep;11(9):RA279-89. Epub 2005 Aug 26. Al-Waili NS1, Butler GJ, Beale J, Hamilton RW, Lee BY, Lucas P.


초록

지난 40년 이상, 고압산소(HBO2) 요법은 다양한 질병에 추천되거나 사용되어져 왔다. 1950년대에 고압산소요법은 최초로 방사선 요법은 물론이고 두경부 암과 자궁경부암을 위한 치료로서 사용되어졌다.


Abstract

Over the past 40 years, hyperbaric oxygen (HBO2) therapy has been recommended and used in a wide variety of medical conditions. In the 1950s, HBO2 was first used as a treatment, in addition to radiation, for head and neck cancers and cervical cancer.


많은 연구들이 암관리(cancer management)의 부분으로서 고압산소요법의 가능한 치료적 효과(therapeutic effects)를 연구하려고 진행되어져 왔다. 근거들은 고압산소요법이 종양 산소포화(tumor oxygenation)를 향상시켰다고 보여주었고, 방사선치료 동안 고압산소를 이용한 치료는 많은 고형 종양의 방사선 반응(radiation response)을 향상시키는 것을 보여주어 왔다.

그것은 지연된 방사선치료 손상과 연부조직과 골 손상, 방광과 장의 증후성 방사선 반응, 후두의 방사선괴사, 방사선치료로 유발된 시각 신경병증, 방사선치료로 유발된 직장염과 방사선치료로 유발된 뇌의 괴사를 위하여 사용되어졌다.

Many studies have been conducted to investigate possible therapeutic effects HBO2 as part of cancer management. Evidences showed that HBO2 improved tumor oxygenation, and treatment with HBO2 during irradiation has been shown to improve the radiation response of many solid tumors. It was used for delayed radiation injuries for soft tissue and bony injuries, for symptomatic radiation reactions of the urinary bladder and the bowel, for laryngeal radionecrosis, for radiation-induced optic neuropathy, for radiation-induced proctitis and for radiation-induced necrosis of the brain.


고압산소요법은 또한 항암화학요법의 민감도(sensitivity)를 증가시킨다.

고산화(hyperoxygenation) 동안 광역동 치료(photodynamic therapy: PDT)가 가해졌을 때 종양 반응에서 중요한 향상이 얻어졌다. 이러한 연구들은 널리 검토되었고 더 나아간 조사들을 위해 이성적인 과학적 기초가 토론되어졌다. 일차성과 이차성 암종을 극복하기 위한 광역동 치료(PDT)와 광감작제(photosensitizer)를 고압산소요법(HBO2)과 결합시키는 것의 가능성은 광범위한 실험과 임상 조사 작업을 받을 만하다.

HBO2 also increases sensitivity to chemotherapy. A significant improvement in tumor response was obtained when photodynamic therapy (PDT) was delivered during hyperoxygenation. These studies were extensively reviewed and rational scientific basis for further investigations was discussed. The possibility of combining HBO2, PDT and photosensitizers to overcome primary and secondary carcinoma deserve extensive laboratory and clinical research works.


고압산소요법은 심지어 활동성 암 환자를 위해서도 사용금지사유(contraindication)가 거의 없이 비교적 무해하다.

HBO2 is a relatively benign with few contraindications, even for active cancer patients.


참고문헌

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